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25 April 2024 |
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Article overview
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Non-transcriptional control of DNA replication by c-Myc | | David Dominguez-Sola
; Carol Y Ying
; Carla Grandori
; Luca Ruggiero
; Brenden Chen
; Muyang Li
; Denise A Galloway
; Wei Gu
; Jean Gautier
; Riccardo Dalla-Favera
; | | Date: |
26 Jul 2007 | | Journal: | Nature, 448 (7152), 445-51 | | Abstract: | The c-Myc proto-oncogene encodes a transcription factor that is essential for cell growth and proliferation and is broadly implicated in tumorigenesis. However, the biological functions required by c-Myc to induce oncogenesis remain elusive. Here we show that c-Myc has a direct role in the control of DNA replication. c-Myc interacts with the pre-replicative complex and localizes to early sites of DNA synthesis. Depletion of c-Myc from mammalian (human and mouse) cells as well as from Xenopus cell-free extracts, which are devoid of RNA transcription, demonstrates a non-transcriptional role for c-Myc in the initiation of DNA replication. Overexpression of c-Myc causes increased replication origin activity with subsequent DNA damage and checkpoint activation. These findings identify a critical function of c-Myc in DNA replication and suggest a novel mechanism for its normal and oncogenic functions. | | Source: | PubMed, pmid17597761 doi: 10.1038/nature05953 | | Services: | Forum | Review | Favorites | |
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