| | |
| | |
Stat |
Members: 3645 Articles: 2'504'585 Articles rated: 2609
24 April 2024 |
|
| | | |
|
Article overview
| |
|
The DNA sequence and biological annotation of human chromosome 1 | S G Gregory
; K F Barlow
; K E McLay
; R Kaul
; D Swarbreck
; A Dunham
; C E Scott
; K L Howe
; K Woodfine
; C C A Spencer
; M C Jones
; C Gillson
; S Searle
; Y Zhou
; F Kokocinski
; L McDonald
; R Evans
; K Phillips
; A Atkinson
; R Cooper
; C Jones
; R E Hall
; T D Andrews
; C Lloyd
; R Ainscough
; J P Almeida
; K D Ambrose
; F Anderson
; R W Andrew
; R I S Ashwell
; K Aubin
; A K Babbage
; C L Bagguley
; J Bailey
; H Beasley
; G Bethel
; C P Bird
; S Bray-Allen
; J Y Brown
; A J Brown
; D Buckley
; J Burton
; J Bye
; C Carder
; J C Chapman
; S Y Clark
; G Clarke
; C Clee
; V Cobley
; R E Collier
; N Corby
; G J Coville
; J Davies
; R Deadman
; M Dunn
; M Earthrowl
; A G Ellington
; H Errington
; A Frankish
; J Frankl
; L French
; P Garner
; J Garnett
; L Gay
; M R J Ghori
; R Gibson
; L M Gilby
; W Gillett
; R J Glithero
; D V Grafham
; C Griffiths
; S Griffiths-Jones
; R Grocock
; S Hammond
; E S I Harrison
; E Hart
; E Haugen
; P D Heath
; S Holmes
; K Holt
; P J Howden
; A R Hunt
; S E Hunt
; G Hunter
; J Isherwood
; R James
; C Johnson
; D Johnson
; A Joy
; M Kay
; J K Kershaw
; M Kibukawa
; A M Kimberley
; A King
; A J Knights
; H Lad
; G Laird
; S Lawlor
; D A Leongamornlert
; D M Lloyd
; J Lovel
; J Lovell
; M J Lush
; R Lyne
; S Martin
; M Mashreghi-Mohammadi
; L Matthews
; N S W Matthews
; S McLaren
; S Milne
; S Mistry
; M J F Moore
; T Nickerson
; C N O’Dell
; K Oliver
; A Palmeiri
; S A Palmer
; A Parker
; D Patel
; A V Pearce
; A I Peck
; S Pelan
; K Phelps
; B J Phillimore
; R Plumb
; J Rajan
; C Raymond
; G Rouse
; C Saenphimmachak
; H K Sehra
; E Sheridan
; R Shownkeen
; S Sims
; C D Skuce
; M Smith
; C Steward
; S Subramanian
; N Sycamore
; A Tracey
; A Tromans
; Z Van Helmond
; M Wall
; J M Wallis
; S White
; S L Whitehead
; J E Wilkinson
; D L Willey
; H Williams
; L Wilming
; P W Wray
; Z Wu
; A Coulson
; M Vaudin
; J E Sulston
; R Durbin
; T Hubbard
; R Wooster
; I Dunham
; N P Carter
; G McVean
; M T Ross
; J Harrow
; M V Olson
; S Beck
; J Rogers
; D R Bentley
; R Banerjee
; S P Bryant
; D C Burford
; W D H Burrill
; S M Clegg
; P Dhami
; O Dovey
; L M Faulkner
; S M Gribble
; C F Langford
; R D Pandian
; K M Porter
; E Prigmore
; | Date: |
18 May 2006 | Journal: | Nature, 441 (7091), 315-21 | Abstract: | The reference sequence for each human chromosome provides the framework for understanding genome function, variation and evolution. Here we report the finished sequence and biological annotation of human chromosome 1. Chromosome 1 is gene-dense, with 3,141 genes and 991 pseudogenes, and many coding sequences overlap. Rearrangements and mutations of chromosome 1 are prevalent in cancer and many other diseases. Patterns of sequence variation reveal signals of recent selection in specific genes that may contribute to human fitness, and also in regions where no function is evident. Fine-scale recombination occurs in hotspots of varying intensity along the sequence, and is enriched near genes. These and other studies of human biology and disease encoded within chromosome 1 are made possible with the highly accurate annotated sequence, as part of the completed set of chromosome sequences that comprise the reference human genome. | Source: | PubMed, pmid16710414 doi: 10.1038/nature04727 | Services: | Forum | Review | Favorites |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
| News, job offers and information for researchers and scientists:
| |