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A microRNA polycistron as a potential human oncogene | | Lin He
; J Michael Thomson
; Michael T Hemann
; Eva Hernando-Monge
; David Mu
; Summer Goodson
; Scott Powers
; Carlos Cordon-Cardo
; Scott W Lowe
; Gregory J Hannon
; Scott M Hammond
; | | Date: |
9 Jun 2005 | | Journal: | Nature, 435 (7043), 828-33 | | Abstract: | To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene. | | Source: | PubMed, pmid15944707 doi: 10.1038/nature03552 | | Services: | Forum | Review | Favorites | |
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