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DNA sequence and analysis of human chromosome 9 | | S J Humphray
; K Oliver
; A R Hunt
; R W Plumb
; J E Lovel
; K L Howe
; T D Andrews
; S Searle
; S E Hunt
; C E Scott
; M C Jones
; R Ainscough
; J P Almeida
; K D Ambrose
; R I S Ashwell
; A K Babbage
; S Babbage
; C L Bagguley
; J Bailey
; R Banerjee
; D J Barker
; K F Barlow
; K Bates
; H Beasley
; O Beasley
; C P Bird
; S Bray-Allen
; A J Brown
; J Y Brown
; D Burford
; W Burrill
; J Burton
; C Carder
; N P Carter
; J C Chapman
; Y Chen
; G Clarke
; S Y Clark
; C M Clee
; S Clegg
; R E Collier
; N Corby
; M Crosier
; A T Cummings
; J Davies
; P Dhami
; M Dunn
; I Dutta
; L W Dyer
; M E Earthrowl
; L Faulkner
; C J Fleming
; A Frankish
; J A Frankl
; L French
; D G Fricker
; P Garner
; J Garnett
; J Ghori
; J G R Gilbert
; C Glison
; D V Grafham
; S Gribble
; C Griffiths
; S Griffiths-Jones
; R Grocock
; J Guy
; R E Hall
; S Hammond
; J L Harley
; E S I Harrison
; E A Hart
; P D Heath
; C D Henderson
; B L Hopkins
; P J Howard
; P J Howden
; E Huckle
; C Johnson
; D Johnson
; A A Joy
; M Kay
; S Keenan
; J K Kershaw
; A M Kimberley
; A King
; A Knights
; G K Laird
; C Langford
; S Lawlor
; D A Leongamornlert
; M Leversha
; C Lloyd
; D M Lloyd
; J Lovell
; S Martin
; M Mashreghi-Mohammadi
; L Matthews
; S McLaren
; K E McLay
; A McMurray
; S Milne
; T Nickerson
; J Nisbett
; G Nordsiek
; A V Pearce
; A I Peck
; K M Porter
; R Pandian
; S Pelan
; B Phillimore
; S Povey
; Y Ramsey
; V R
; M Scharfe
; H K Sehra
; R Shownkeen
; S K Sims
; C D Skuce
; M Smith
; C A Steward
; D Swarbreck
; N Sycamore
; J Tester
; A Thorpe
; A Tracey
; A Tromans
; D W Thomas
; M Wall
; J M Wallis
; A P West
; S L Whitehead
; D L Willey
; S A Williams
; L Wilming
; P W Wray
; L Young
; J L Ashurst
; A Coulson
; H Blöcker
; R Durbin
; J E Sulston
; T Hubbard
; M J Jackson
; D R Bentley
; S Beck
; J Rogers
; I Dunham
; | | Date: |
27 May 2004 | | Journal: | Nature, 429 (6990), 369-74 | | Abstract: | Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises 109,044,351 base pairs and represents >99.6% of the region. Analysis of the sequence reveals many intra- and interchromosomal duplications, including segmental duplications adjacent to both the centromere and the large heterochromatic block. We have annotated 1,149 genes, including genes implicated in male-to-female sex reversal, cancer and neurodegenerative disease, and 426 pseudogenes. The chromosome contains the largest interferon gene cluster in the human genome. There is also a region of exceptionally high gene and G + C content including genes paralogous to those in the major histocompatibility complex. We have also detected recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection. | | Source: | PubMed, pmid15164053 doi: 10.1038/nature02465 | | Services: | Forum | Review | Favorites | |
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