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25 April 2024 |
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The DNA sequence and biology of human chromosome 19 | | Jane Grimwood
; Laurie A Gordon
; Anne Olsen
; Astrid Terry
; Jeremy Schmutz
; Jane Lamerdin
; Uffe Hellsten
; David Goodstein
; Olivier Couronne
; Mary Tran-Gyamfi
; Andrea Aerts
; Michael Altherr
; Linda Ashworth
; Eva Bajorek
; Stacey Black
; Elbert Branscomb
; Sean Caenepeel
; Anthony Carrano
; Chenier Caoile
; Yee Man Chan
; Mari Christensen
; Catherine A Clel
; Alex Copel
; Eileen Dalin
; Paramvir Dehal
; Mirian Denys
; John C Detter
; Julio Escobar
; Dave Flowers
; Dea Fotopulos
; Carmen Garcia
; Anca M Georgescu
; Tijana Glavina
; Maria Gomez
; Eidelyn Gonzales
; Matthew Groza
; Nancy Hammon
; Trevor Hawkins
; Lauren Haydu
; Isaac Ho
; Wayne Huang
; Sanjay Israni
; Jamie Jett
; Kristen Kadner
; Heather Kimball
; Arthur Kobayashi
; Vladimer Larionov
; Sun-Hee Leem
; Frederick Lopez
; Yunian Lou
; Steve Lowry
; Stephanie Malfatti
; Diego Martinez
; Paula McCready
; Catherine Medina
; Jenna Morgan
; Kathryn Nelson
; Matt Nolan
; Ivan Ovcharenko
; Sam Pitluck
; Martin Pollard
; Anthony P Popkie
; Paul Predki
; Glenda Quan
; Lucia Ramirez
; Sam Rash
; James Retterer
; Alex Rodriguez
; Stephanine Rogers
; Asaf Salamov
; Angelica Salazar
; Xinwei She
; Doug Smith
; Tom Slezak
; Victor Solovyev
; Nina Thayer
; Hope Tice
; Ming Tsai
; Anna Ustaszewska
; Nu Vo
; Mark Wagner
; Jeremy Wheeler
; Kevin Wu
; Gary Xie
; Joan Yang
; Inna Dubchak
; Terrence S Furey
; Pieter DeJong
; Mark Dickson
; David Gordon
; Evan E Eichler
; Len A Pennacchio
; Paul Richardson
; Lisa Stubbs
; Daniel S Rokhsar
; Richard M Myers
; Edward M Rubin
; Susan M Lucas
; | | Date: |
1 Apr 2004 | | Journal: | Nature, 428 (6982), 529-35 | | Abstract: | Chromosome 19 has the highest gene density of all human chromosomes, more than double the genome-wide average. The large clustered gene families, corresponding high G + C content, CpG islands and density of repetitive DNA indicate a chromosome rich in biological and evolutionary significance. Here we describe 55.8 million base pairs of highly accurate finished sequence representing 99.9% of the euchromatin portion of the chromosome. Manual curation of gene loci reveals 1,461 protein-coding genes and 321 pseudogenes. Among these are genes directly implicated in mendelian disorders, including familial hypercholesterolaemia and insulin-resistant diabetes. Nearly one-quarter of these genes belong to tandemly arranged families, encompassing more than 25% of the chromosome. Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu. | | Source: | PubMed, pmid15057824 doi: 10.1038/nature02399 | | Services: | Forum | Review | Favorites | |
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