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28 March 2024
 
  » pubmed » pmid14574404

 Article overview


The DNA sequence and analysis of human chromosome 6
A J Mungall ; S A Palmer ; S K Sims ; C A Edwards ; J L Ashurst ; L Wilming ; M C Jones ; R Horton ; S E Hunt ; C E Scott ; J G R Gilbert ; M E Clamp ; G Bethel ; S Milne ; R Ainscough ; J P Almeida ; K D Ambrose ; T D Andrews ; R I S Ashwell ; A K Babbage ; C L Bagguley ; J Bailey ; R Banerjee ; D J Barker ; K F Barlow ; K Bates ; D M Beare ; H Beasley ; O Beasley ; C P Bird ; S Blakey ; S Bray-Allen ; J Brook ; A J Brown ; J Y Brown ; D C Burford ; W Burrill ; J Burton ; C Carder ; N P Carter ; J C Chapman ; S Y Clark ; G Clark ; C M Clee ; S Clegg ; V Cobley ; R E Collier ; J E Collins ; L K Colman ; N R Corby ; G J Coville ; K M Culley ; P Dhami ; J Davies ; M Dunn ; M E Earthrowl ; A E Ellington ; K A Evans ; L Faulkner ; M D Francis ; A Frankish ; J Frankl ; L French ; P Garner ; J Garnett ; M J R Ghori ; L M Gilby ; C J Gillson ; R J Glithero ; D V Grafham ; M Grant ; S Gribble ; C Griffiths ; M Griffiths ; R Hall ; K S Halls ; S Hammond ; J L Harley ; E A Hart ; P D Heath ; R Heathcott ; S J Holmes ; P J Howden ; K L Howe ; G R Howell ; E Huckle ; S J Humphray ; M D Humphries ; A R Hunt ; C M Johnson ; A A Joy ; M Kay ; S J Keenan ; A M Kimberley ; A King ; G K Laird ; C Langford ; S Lawlor ; D A Leongamornlert ; M Leversha ; C R Lloyd ; D M Lloyd ; J E Lovel ; J Lovell ; S Martin ; M Mashreghi-Mohammadi ; G L Maslen ; L Matthews ; O T McCann ; S J McLaren ; K McLay ; A McMurray ; M J F Moore ; J C Mullikin ; D Niblett ; T Nickerson ; K L Novik ; K Oliver ; E K Overton-Larty ; A Parker ; R Patel ; A V Pearce ; A I Peck ; B Phillimore ; S Phillips ; R W Plumb ; K M Porter ; Y Ramsey ; S A Ranby ; C M Rice ; M T Ross ; S M Searle ; H K Sehra ; E Sheridan ; C D Skuce ; S Smith ; M Smith ; L Spraggon ; S L Squares ; C A Steward ; N Sycamore ; G Tamlyn-Hall ; J Tester ; A J Theaker ; D W Thomas ; A Thorpe ; A Tracey ; A Tromans ; B Tubby ; M Wall ; J M Wallis ; A P West ; S S White ; S L Whitehead ; H Whittaker ; A Wild ; D J Willey ; T E Wilmer ; J M Wood ; P W Wray ; J C Wyatt ; L Young ; R M Younger ; D R Bentley ; A Coulson ; R Durbin ; T Hubbard ; J E Sulston ; I Dunham ; J Rogers ; S Beck ;
Date 23 Oct 2003
Journal Nature, 425 (6960), 805-11
AbstractChromosome 6 is a metacentric chromosome that constitutes about 6% of the human genome. The finished sequence comprises 166,880,988 base pairs, representing the largest chromosome sequenced so far. The entire sequence has been subjected to high-quality manual annotation, resulting in the evidence-supported identification of 1,557 genes and 633 pseudogenes. Here we report that at least 96% of the protein-coding genes have been identified, as assessed by multi-species comparative sequence analysis, and provide evidence for the presence of further, otherwise unsupported exons/genes. Among these are genes directly implicated in cancer, schizophrenia, autoimmunity and many other diseases. Chromosome 6 harbours the largest transfer RNA gene cluster in the genome; we show that this cluster co-localizes with a region of high transcriptional activity. Within the essential immune loci of the major histocompatibility complex, we find HLA-B to be the most polymorphic gene on chromosome 6 and in the human genome.
Source PubMed, pmid14574404 doi: 10.1038/nature02055
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