|
| | | | |
| | | |
| Stat |
Members: 3645
Articles: 2'501'711
Articles rated: 2609
20 April 2024 |
|
| | | | |
|
Article overview
| |
|
|
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing | | Shuang-Xi Ren
; Gang Fu
; Xiu-Gao Jiang
; Rong Zeng
; You-Gang Miao
; Hai Xu
; Yi-Xuan Zhang
; Hui Xiong
; Gang Lu
; Ling-Feng Lu
; Hong-Quan Jiang
; Jia Jia
; Yue-Feng Tu
; Ju-Xing Jiang
; Wen-Yi Gu
; Yue-Qing Zhang
; Zhen Cai
; Hai-Hui Sheng
; Hai-Feng Yin
; Yi Zhang
; Gen-Feng Zhu
; Ma Wan
; Hong-Lei Huang
; Zhen Qian
; Sheng-Yue Wang
; Wei Ma
; Zhi-Jian Yao
; Yan Shen
; Bo-Qin Qiang
; Qi-Chang Xia
; Xiao-Kui Guo
; Antoine Danchin
; Isabelle Saint Girons
; Ronald L Somerville
; Yu-Mei Wen
; Man-Hua Shi
; Zhu Chen
; Jian-Guo Xu
; Guo-Ping Zhao
; | | Date: |
24 Apr 2003 | | Journal: | Nature, 422 (6934), 888-93 | | Abstract: | Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur. Here we report the complete genomic sequence of a representative virulent serovar type strain (Lai) of Leptospira interrogans serogroup Icterohaemorrhagiae consisting of a 4.33-megabase large chromosome and a 359-kilobase small chromosome, with a total of 4,768 predicted genes. In terms of the genetic determinants of physiological characteristics, the facultatively parasitic L. interrogans differs extensively from two other strictly parasitic pathogenic spirochaetes, Treponema pallidum and Borrelia burgdorferi, although similarities exist in the genes that govern their unique morphological features. A comprehensive analysis of the L. interrogans genes for chemotaxis/motility and lipopolysaccharide synthesis provides a basis for in-depth studies of virulence and pathogenesis. The discovery of a series of genes possibly related to adhesion, invasion and the haematological changes that characterize leptospirosis has provided clues about how an environmental organism might evolve into an important human pathogen. | | Source: | PubMed, pmid12712204 doi: 10.1038/nature01597 | | Services: | Forum | Review | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
|
News, job offers and information for researchers and scientists:
| |
REGISTER