| | |
| | |
Stat |
Members: 3645 Articles: 2'501'711 Articles rated: 2609
19 April 2024 |
|
| | | |
|
Article overview
| |
|
A gene expression map of human chromosome 21 orthologues in the mouse | Yorick Gitton
; Nadia Dahmane
; Sonya Baik
; Ariel Ruiz i Altaba
; Lorenz Neidhardt
; Manuela Scholze
; Bernhard G Herrmann
; Pascal Kahlem
; Alia Benkahla
; Sabine Schrinner
; Reha Yildirimman
; Ralf Herwig
; Hans Lehrach
; Marie-Laure Yaspo
;
; | Date: |
5 Dec 2002 | Journal: | Nature, 420 (6915), 586-90 | Abstract: | The DNA sequence of human chromosome 21 (HSA21) has opened the route for a systematic molecular characterization of all of its genes. Trisomy 21 is associated with Down’s syndrome, the most common genetic cause of mental retardation in humans. The phenotype includes various organ dysmorphies, stereotypic craniofacial anomalies and brain malformations. Molecular analysis of congenital aneuploidies poses a particular challenge because the aneuploid region contains many protein-coding genes whose function is unknown. One essential step towards understanding their function is to analyse mRNA expression patterns at key stages of organism development. Seminal works in flies, frogs and mice showed that genes whose expression is restricted spatially and/or temporally are often linked with specific ontogenic processes. Here we describe expression profiles of mouse orthologues to HSA21 genes by a combination of large-scale mRNA in situ hybridization at critical stages of embryonic and brain development and in silico (computed) mining of expressed sequence tags. This chromosome-scale expression annotation associates many of the genes tested with a potential biological role and suggests candidates for the pathogenesis of Down’s syndrome. | Source: | PubMed, pmid12466855 doi: 10.1038/nature01270 | Services: | Forum | Review | Favorites |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
| News, job offers and information for researchers and scientists:
| |