|
| | | | |
| | | |
| Stat |
Members: 3645
Articles: 2'504'585
Articles rated: 2609
25 April 2024 |
|
| | | | |
|
Article overview
| |
|
|
The harlequin mouse mutation downregulates apoptosis-inducing factor | | Jeffrey A Klein
; Chantal M Longo-Guess
; Marlies P Rossmann
; Kevin L Seburn
; Ronald E Hurd
; Wayne N Frankel
; Roderick T Bronson
; Susan L Ackerman
; | | Date: |
26 Sep 2002 | | Journal: | Nature, 419 (6905), 367-74 | | Abstract: | Harlequin (Hq) mutant mice have progressive degeneration of terminally differentiated cerebellar and retinal neurons. We have identified the Hq mutation as a proviral insertion in the apoptosis-inducing factor (Aif) gene, causing about an 80% reduction in AIF expression. Mutant cerebellar granule cells are susceptible to exogenous and endogenous peroxide-mediated apoptosis, but can be rescued by AIF expression. Overexpression of AIF in wild-type granule cells further decreases peroxide-mediated cell death, suggesting that AIF serves as a free radical scavenger. In agreement, dying neurons in aged Hq mutant mice show oxidative stress. In addition, neurons damaged by oxidative stress in both the cerebellum and retina of Hq mutant mice re-enter the cell cycle before undergoing apoptosis. Our results provide a genetic model of oxidative stress-mediated neurodegeneration and demonstrate a direct connection between cell cycle re-entry and oxidative stress in the ageing central nervous system. | | Source: | PubMed, pmid12353028 doi: 10.1038/nature01034 | | Services: | Forum | Review | Favorites | |
|
|
No review found.
Did you like this article?
Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.
browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)
|
| |
|
|
|
|
News, job offers and information for researchers and scientists:
| |
REGISTER