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Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters | | M Koranda
; A Schleiffer
; L Endler
; G Ammerer
; | | Date: |
6 Jul 2000 | | Journal: | Nature, 406 (6791), 94-8 | | Abstract: | Many cell-cycle-specific events are supported by stage-specific gene expression. In budding yeast, at least three different nuclear factors seem to cooperate in the periodic activation of G2/M-specific genes. Here we show, by using chromatin immunoprecipitation polymerase chain reaction assays, that a positive regulator, Ndd1, becomes associated with G2/M promoter regions in manner that depends on the stage in cell cycle. Its recruitment depends on a permanent protein-DNA complex consisting of the MADS box protein, Mcm1, and a recently identified partner Fkh2, a forkhead/winged helix related transcription factor. The lethality of Ndd1 depletion is suppressed by fkh2 null mutations, which indicates that Fkh2 may also have a negative regulatory role in the transcription of G2/M-induced RNAs. We conclude that Ndd1-Fkh2 interactions may be the transcriptionally important process targeted by Cdk activity. | | Source: | PubMed, pmid10894549 doi: 10.1038/35017589 | | Services: | Forum | Review | Favorites | |
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