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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants | | J Taub
; J F Lau
; C Ma
; J H Hahn
; R Hoque
; J Rothblatt
; M Chalfie
; | | Date: |
13 May 1999 | | Journal: | Nature, 399 (6732), 162-6 | | Abstract: | The dauer larva is an alternative larval stage in Caenorhabditis elegans which allows animals to survive through periods of low food availability. Well-fed worms live for about three weeks, but dauer larvae can live for at least two months without affecting post-dauer lifespan. Mutations in daf-2 and age-1, which produce a dauer constitutive (Daf-C) phenotype, and in clk-1, which are believed to slow metabolism, markedly increase adult lifespan. Here we show that a ctl-1 mutation reduces adult lifespan in otherwise wild-type animals and eliminates the daf-c and clk-1-mediated extension of adult lifespan. ctl-1 encodes an unusual cytosolic catalase; a second gene, ctl-2, encodes a peroxisomal catalase. ctl-1 messenger RNA is increased in dauer larvae and adults with the daf-c mutations. We suggest that the ctl-1 catalase is needed during periods of starvation, as in the dauer larva, and that its misexpression in daf-c and clk-1 adults extends lifespan. Cytosolic catalase may have evolved to protect nematodes from oxidative damage produced during prolonged dormancy before reproductive maturity, or it may represent a general mechanism for permitting organisms to cope with the metabolic changes that accompany starvation. | | Source: | PubMed, pmid10335847 doi: 10.1038/20208 | | Other source: | [GID 464648] pmid12610632 | | Services: | Forum | Review | Favorites | |
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