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Male-to-female sex reversal in M33 mutant mice | | Y Katoh-Fukui
; R Tsuchiya
; T Shiroishi
; Y Nakahara
; N Hashimoto
; K Noguchi
; T Higashinakagawa
; | | Date: |
18 Jun 1998 | | Journal: | Nature, 393 (6686), 688-92 | | Abstract: | Polycomb genes in Drosophila maintain the repressed state of homeotic and other developmentally regulated genes by mediating changes in higher-order chromatin structure. M33, a mouse homologue of Polycomb, was isolated by means of the structural similarity of its chromodomain. The fifth exon of M33 contains a region of homology shared by Drosophila and Xenopus. In Drosophila, its deletion results in the loss of Polycomb function. Here we have disrupted M33 in mice by inserting a poly(A) capture-type neo(r) targeting vector into its fifth exon. More than half of the resultant M33cterm/M33cterm mutant mice died before weaning, and survivors showed male-to-female sex reversal. Formation of genital ridges was retarded in both XX and XY M33cterm/M33cterm embryos. Gonadal growth defects appeared near the time of expression of the Y-chromosome-specific Sry gene, suggesting that M33 deficiency may cause sex reversal by interfering with steps upstream of Sry. M33cterm/M33cterm mice may be a valuable model in which to test opposing views regarding sex determination. | | Source: | PubMed, pmid9641679 doi: 10.1038/31482 | | Services: | Forum | Review | Favorites | |
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