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29 March 2024 |
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Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas | T Brunner
; R J Mogil
; D LaFace
; N J Yoo
; A Mahboubi
; F Echeverri
; S J Martin
; W R Force
; D H Lynch
; C F Ware
; | Date: |
2 Feb 1995 | Journal: | Nature, 373 (6513), 441-4 | Abstract: | A number of murine T-cell hybridomas undergo apoptosis within a few hours of activation by specific antigens, mitogens, antibodies against the T-cell antigen receptor, or a combination of phorbol ester and calcium ionophore. This phenomenon has been extensively studied as a model for clonal deletion in the immune system, in which potentially autoreactive T cells eliminate themselves by apoptosis after activation, either in the thymus or in the periphery. Here we show that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligand, is rapidly expressed following activation of T-cell hybridomas, as is its functional, membrane-bound ligand. Interference with the ensuing Fas/Fas-ligand interaction inhibits activation-induced apoptosis. Because T-cell receptor ligation can induce apoptosis in a single T hybridoma cell, we suggest that the Fas/Fas-ligand interaction can induce cell death in a cell-autonomous manner. | Source: | PubMed, pmid7530336 doi: 10.1038/373441a0 | Services: | Forum | Review | Favorites |
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