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29 March 2024
 
  » pubmed » pmid7530336

 Article overview


Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
T Brunner ; R J Mogil ; D LaFace ; N J Yoo ; A Mahboubi ; F Echeverri ; S J Martin ; W R Force ; D H Lynch ; C F Ware ;
Date 2 Feb 1995
Journal Nature, 373 (6513), 441-4
AbstractA number of murine T-cell hybridomas undergo apoptosis within a few hours of activation by specific antigens, mitogens, antibodies against the T-cell antigen receptor, or a combination of phorbol ester and calcium ionophore. This phenomenon has been extensively studied as a model for clonal deletion in the immune system, in which potentially autoreactive T cells eliminate themselves by apoptosis after activation, either in the thymus or in the periphery. Here we show that the Fas/CD95 receptor, which can transduce a potent apoptotic signal when ligand, is rapidly expressed following activation of T-cell hybridomas, as is its functional, membrane-bound ligand. Interference with the ensuing Fas/Fas-ligand interaction inhibits activation-induced apoptosis. Because T-cell receptor ligation can induce apoptosis in a single T hybridoma cell, we suggest that the Fas/Fas-ligand interaction can induce cell death in a cell-autonomous manner.
Source PubMed, pmid7530336 doi: 10.1038/373441a0
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