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29 March 2024
 
  » pubmed » pmid8107848

 Article overview


Cloning of a pH-sensitive K+ channel possessing two transmembrane segments
M Suzuki ; K Takahashi ; M Ikeda ; H Hayakawa ; A Ogawa ; Y Kawaguchi ; O Sakai ;
Date 17 Feb 1994
Journal Nature, 367 (6464), 642-5
AbstractThe mammalian renal collecting ducts are responsible for secreting potassium ions into the urine and are a major regulatory site for potassium homeostasis, in which a voltage-independent pH-sensitive K+ channel in the apical membrane plays a central role. Here we describe a complementary DNA encoding a novel K+ channel from rabbit renal cortical collecting tubule cells (RACTK1). RACTK1 has the functional characteristics of the apical K(+)-permeable channel and consists of 284 amino acids, putatively with two transmembrane segments. The sequence of RACTK1, however, shows no homology to known voltage-dependent or -independent K+ channels, and has a different K(+)-driving path and regulatory sites. The study of this protein should provide insight into K+ homeostasis and diseases of K+ metabolism.
Source PubMed, pmid8107848 doi: 10.1038/367642a0
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