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Article overview
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Cloning of a pH-sensitive K+ channel possessing two transmembrane segments | M Suzuki
; K Takahashi
; M Ikeda
; H Hayakawa
; A Ogawa
; Y Kawaguchi
; O Sakai
; | Date: |
17 Feb 1994 | Journal: | Nature, 367 (6464), 642-5 | Abstract: | The mammalian renal collecting ducts are responsible for secreting potassium ions into the urine and are a major regulatory site for potassium homeostasis, in which a voltage-independent pH-sensitive K+ channel in the apical membrane plays a central role. Here we describe a complementary DNA encoding a novel K+ channel from rabbit renal cortical collecting tubule cells (RACTK1). RACTK1 has the functional characteristics of the apical K(+)-permeable channel and consists of 284 amino acids, putatively with two transmembrane segments. The sequence of RACTK1, however, shows no homology to known voltage-dependent or -independent K+ channels, and has a different K(+)-driving path and regulatory sites. The study of this protein should provide insight into K+ homeostasis and diseases of K+ metabolism. | Source: | PubMed, pmid8107848 doi: 10.1038/367642a0 | Services: | Forum | Review | Favorites |
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