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19 April 2024 |
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A retinoblastoma-binding protein related to a negative regulator of Ras in yeast | | Y W Qian
; Y C Wang
; R E Hollingsworth
; D Jones
; N Ling
; E Y Lee
; | | Date: |
12 Aug 1993 | | Journal: | Nature, 364 (6438), 648-52 | | Abstract: | The growth suppression function of the retinoblastoma protein (Rb) is though to be mediated by Rb binding to cellular proteins. p48 is one of the major proteins that binds to a putative functional domain at the carboxy terminus of the Rb protein. Here we report the isolation of a full-length complementary DNA (RbAp48) encoding p48. Complex formation between p48 and Rb occurs in vitro and in vivo, and apparently involves direct interaction between the proteins. Like Rb, p48 is a ubiquitously expressed nuclear protein. RbAp48 share sequence homology with MSI1, a negative regulator of the Ras-cyclic AMP pathway in the yeast Saccharomyces cerevisiae. Furthermore, like MSI1, human RbAp48 suppresses the heat-shock sensitivity of the yeast ira1 strains and RAS2Val19 strains. Interaction with p48 may be one of the mechanisms for suppression of growth mediated by Rb. | | Source: | PubMed, pmid8350924 doi: 10.1038/364648a0 | | Services: | Forum | Review | Favorites | |
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