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Article overview
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The folding of hen lysozyme involves partially structured intermediates and multiple pathways | S E Radford
; C M Dobson
; P A Evans
; | Date: |
23 Jul 1992 | Journal: | Nature, 358 (6384), 302-7 | Abstract: | Analysis of the folding of hen lysozyme shows that the protein does not become organized in a single cooperative event but that different parts of the structure become stabilized with very different kinetics. In particular, in most molecules the alpha-helical domain folds faster than the beta-sheet domain. Furthermore, different populations of molecules fold by kinetically distinct pathways. Thus, folding is not a simple sequential assembly process but involves parallel alternative pathways, some of which may involve substantial reorganization steps. | Source: | PubMed, pmid1641003 doi: 10.1038/358302a0 | Services: | Forum | Review | Favorites |
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