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19 April 2024

» pubmed » pmid1865923

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Common west African HLA antigens are associated with protection from severe malaria
A V Hill ; C E Allsopp ; D Kwiatkowski ; N M Anstey ; P Twumasi ; P A Rowe ; S Bennett ; D Brewster ; A J McMichael ; B M Greenwood ;
Date:	15 Aug 1991
Journal:	Nature, 352 (6336), 595-600
Abstract:	A large case-control study of malaria in West African children shows that a human leucocyte class I antigen (HLA-Bw53) and an HLA class II haplotype (DRB11302-DQB10501), common in West Africans but rare in other racial groups, are independently associated with protection from severe malaria. In this population they account for as great a reduction in disease incidence as the sickle-cell haemoglobin variant. These data support the hypothesis that the extraordinary polymorphism of major histocompatibility complex genes has evolved primarily through natural selection by infectious pathogens.
Source:	PubMed, pmid1865923 doi: 10.1038/352595a0
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