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25 April 2024

» pubmed » pmid2961997

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T-cell receptor delta gene rearrangements in early thymocytes
Y H Chien ; M Iwashima ; D A Wettstein ; K B Kaplan ; J F Elliott ; W Born ; M M Davis ;
Date:	24 Dec 1987
Journal:	Nature, 330 (6150), 722-7
Abstract:	The T-cell receptor delta-chain variable region can be assembled from as many as four distinct gene segments, V, D1, D2 and J, more than any other antigen-receptor gene. In fetal thymocytes V----D joinings are as common as D----J or VDJ rearrangements and one V gene segment predominates. Analysis of rearrangements at TCR gamma and delta loci during fetal ontogeny suggests abrupt changes and possible coordinate control in the rearrangement and expression of these loci.
Source:	PubMed, pmid2961997 doi: 10.1038/330722a0
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