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25 April 2024

» pubmed » pmid3027582

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Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes
T Saito ; A Weiss ; J Miller ; M A Norcross ; R N Germain ;
Date:	8 Jan 1987
Journal:	Nature, 325 (7000), 125-30
Abstract:	The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex. Only the complete murine Ti alpha beta dimer mediates specific functional corecognition of the appropriate antigen-Ia pair.
Source:	PubMed, pmid3027582 doi: 10.1038/325125a0
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