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19 April 2024 |
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Article overview
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Limited diversity of the rearranged T-cell gamma gene | D M Kranz
; H Saito
; M Heller
; Y Takagaki
; W Haas
; H N Eisen
; S Tonegawa
; | Date: |
6 Feb 1985 | Journal: | Nature, 313 (6005), 752-5 | Abstract: | The immunoglobulin-related, T-cell specific gamma gene is rearranged in a wide variety of murine T lymphocytes. We detected gamma-gene transcripts in all cloned cytotoxic T lymphocytes examined but in only 1 of 11 T-helper cell lines or hybridomas. Although in cytotoxic T cells, the rearranged gamma gene seems to have been assembled from the same germ-line variable and joining gene segments, the transcribed gene exhibited distinct sequence diversity near the junction between these segments. | Source: | PubMed, pmid3871915 | Services: | Forum | Review | Favorites |
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