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Loss of a Harvey ras allele in sporadic Wilms' tumour | A E Reeve
; P J Housiaux
; R J Gardner
; W E Chewings
; R M Grindley
; L J Millow
; | Date: |
10 May 1984 | Journal: | Nature, 309 (5964), 174-6 | Abstract: | Genomic changes within chromosome band 11p13 appear to have a role in the initiation of Wilms’ tumour. The human Harvey ras oncogene, c-Ha-ras 1, has been located by Jhanwar et al. immediately adjacent to this region at band 11p14 .1, although several groups have assigned the gene more distally at band 11p15 . We have examined tumour DNA from two cases of sporadic Wilms’ tumour, and report here that in both cases one of the two constitutional c-Ha-ras 1 alleles was absent. One tumour had a reciprocal translocation between the short arm of chromosome 11 (at band 11p13), and the long arm of chromosome 12, with no visible loss of chromosomal material. The loss of a c-Ha-ras 1 allele in association with this translocation indicates that a submicroscopic deletion had occurred. The resulting hemizygosity may have had a role in tumour initiation. Our results indicate that the c-Ha-ras 1 gene and the ’Wilms’ tumour locus’ may be in close proximity. It would, therefore, be premature to exclude the possibility that these two sites are functionally related. | Source: | PubMed, pmid6325938 | Services: | Forum | Review | Favorites |
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