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20 April 2024

» pubmed » pmid6417542

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Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement
P D Burrows ; G B Beck-Engeser ; M R Wabl ;
Date:	17 Nov 1983
Journal:	Nature, 306 (5940), 243-6
Abstract:	Switching of an Abelson virus-transformed mouse lymphoid cell line from immunoglobulin mu to gamma 2b heavy-chain synthesis in vitro is accompanied by loss of DNA sequences between the JH and C gamma 2b gene segments, and thus cannot be explained by differential RNA processing. The light-chain loci of both mu- and gamma 2b-producing cell clones are in the embryonic configuration, which indicates that class switching can occur in pre-B cells.
Source:	PubMed, pmid6417542
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