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Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor | | M Capron
; A Capron
; E J Goetzl
; K F Austen
; | | Date: |
1 Jan 1981 | | Journal: | Nature, 289 (5793), 71-3 | | Abstract: | Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. Amino acid substitutions or modifications of the ECF-A tetrapeptides may substantially alter the chemotactic activity of human eosinophils. The cellular mechanism whereby ECF-A tetrapeptides enhance IgG-dependent killing of schistosomula by rat eosinophils is, however, unclear. We now report that the parent tetrapeptides and the substituted analogue Val-Pro-Ser-Glu (Pro3), but not histamine, increase the number of rat and human eosinophils that form rosettes with erythrocytes bearing IgG antibodies. Moreover, we find a correlation between the effect of these substances on the expression of rat eosinophil IgG Fc receptors and their capacity to increase the IgG-dependent cytotoxicity of rat eosinophils for Schistosoma mansoni schistosomula. | | Source: | PubMed, pmid7453810 | | Services: | Forum | Review | Favorites | |
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