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29 March 2024
 
  » pubmed » pmid6157094

 Article overview


Isolation and structure of a human fibroblast interferon gene
R Derynck ; J Content ; E DeClercq ; G Volckaert ; J Tavernier ; R Devos ; W Fiers ;
Date 19 Jun 1980
Journal Nature, 285 (5766), 542-7
AbstractChimaeric plasmids containing double-stranded cDNA copies of mRNA induced in human fibroblasts by poly I . C were screened by an RNA selection method. A series of clones to which human fibroblast interferon mRNA selectively hybridized was identified. From the nucleotide sequence of the gene, the complete amino acid sequence of human fibroblast interferon was deduced. The protein is 166 amino acids long and is preceded by a 21-amino acid signal sequence.
Source PubMed, pmid6157094
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