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23 April 2024

» pubmed » pmid17641165

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A whole-genome association study of major determinants for host control of HIV-1
Jacques Fellay ; Kevin V Shianna ; Dongliang Ge ; Sara Colombo ; Bruno Ledergerber ; Mike Weale ; Kunlin Zhang ; Curtis Gumbs ; Antonella Castagna ; Andrea Cossarizza ; Alessandro Cozzi-Lepri ; Andrea De Luca ; Philippa Easterbrook ; Patrick Francioli ; Simon Mallal ; Javier Martinez-Picado ; José M Miro ; Niels Obel ; Jason P Smith ; Josiane Wyniger ; Patrick Descombes ; Stylianos E Antonarakis ; Norman L Letvin ; Andrew J McMichael ; Barton F Haynes ; Amalio Telenti ; David B Goldstein ;
Date:	17 Aug 2007
Journal:	Science, 317 (5840), 944-7
Abstract:	Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Source:	PubMed, pmid17641165 doi: 10.1126/science.1143767
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