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29 March 2024
 
  » pubmed » pmid17626846

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Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination
Mei Ding ; Dan Chao ; George Wang ; Kang Shen ;
Date 17 Aug 2007
Journal Science, 317 (5840), 947-51
AbstractStereotyped synaptic connectivity can arise both by precise recognition between appropriate partners during synaptogenesis and by selective synapse elimination. The molecular mechanisms that underlie selective synapse removal are largely unknown. We found that stereotyped developmental elimination of synapses in the Caenorhabditis elegans hermaphrodite-specific motor neuron (HSNL) was mediated by an E3 ubiquitin ligase, a Skp1-cullin-F-box (SCF) complex composed of SKR-1 and the F-box protein SEL-10. SYG-1, a synaptic adhesion molecule, bound to SKR-1 and inhibited assembly of the SCF complex, thereby protecting nearby synapses. Thus, subcellular regulation of ubiquitin-mediated protein degradation contributes to precise synaptic connectivity through selective synapse elimination.
Source PubMed, pmid17626846 doi: 10.1126/science.1145727
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