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Genome sequence of Aedes aegypti, a major arbovirus vector | | Vishvanath Nene
; Jennifer R Wortman
; Daniel Lawson
; Brian Haas
; Chinnappa Kodira
; Zhijian Jake Tu
; Brendan Loftus
; Zhiyong Xi
; Karyn Megy
; Manfred Grabherr
; Quinghu Ren
; Evgeny M Zdobnov
; Neil F Lobo
; Kathryn S Campbell
; Susan E Brown
; Maria F Bonaldo
; Jingsong Zhu
; Steven P Sinkins
; David G Hogenkamp
; Paolo Amedeo
; Peter Arensburger
; Peter W Atkinson
; Shelby Bidwell
; Jim Biedler
; Ewan Birney
; Robert V Bruggner
; Javier Costas
; Monique R Coy
; Jonathan Crabtree
; Matt Crawford
; Becky Debruyn
; David Decaprio
; Karin Eiglmeier
; Eric Eisenstadt
; Hamza El-Dorry
; William M Gelbart
; Suely L Gomes
; Martin Hammond
; Linda I Hannick
; James R Hogan
; Michael H Holmes
; David Jaffe
; J Spencer Johnston
; Ryan C Kennedy
; Hean Koo
; Saul Kravitz
; Evgenia V Kriventseva
; David Kulp
; Kurt Labutti
; Eduardo Lee
; Song Li
; Diane D Lovin
; Chunhong Mao
; Evan Mauceli
; Carlos F M Menck
; Jason R Miller
; Philip Montgomery
; Akio Mori
; Ana L Nascimento
; Horacio F Naveira
; Chad Nusbaum
; Sinéad O’leary
; Joshua Orvis
; Mihaela Pertea
; Hadi Quesneville
; Kyanne R Reidenbach
; Yu-Hui Rogers
; Charles W Roth
; Jennifer R Schneider
; Michael Schatz
; Martin Shumway
; Mario Stanke
; Eric O Stinson
; Jose M C Tubio
; Janice P Vanzee
; Sergio Verjovski-Almeida
; Doreen Werner
; Owen White
; Stefan Wyder
; Qiandong Zeng
; Qi Zhao
; Yongmei Zhao
; Catherine A Hill
; Alexander S Raikhel
; Marcelo B Soares
; Dennis L Knudson
; Norman H Lee
; James Galagan
; Steven L Salzberg
; Ian T Paulsen
; George Dimopoulos
; Frank H Collins
; Bruce Birren
; Claire M Fraser-Liggett
; David W Severson
; | | Date: |
22 Jun 2007 | | Journal: | Science, 316 (5832), 1718-23 | | Abstract: | We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species. | | Source: | PubMed, pmid17510324 doi: 10.1126/science.1138878 | | Services: | Forum | Review | Favorites | |
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