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29 March 2024
 
  » pubmed » pmid17218525

 Article overview


Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
Heather J Melichar ; Kavitha Narayan ; Sandy D Der ; Yoshiki Hiraoka ; Noemie Gardiol ; Gregoire Jeannet ; Werner Held ; Cynthia A Chambers ; Joonsoo Kang ;
Date 12 Jan 2007
Journal Science, 315 (5809), 230-3
Abstractalphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes gammadelta T cell development while opposing alphabeta T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of gammadelta T cells but not alphabeta T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.
Source PubMed, pmid17218525 doi: 10.1126/science.1135344
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