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17 April 2024 |
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Untemplated oligoadenylation promotes degradation of RISC-cleaved transcripts | Fadia Ibrahim
; Jennifer Rohr
; Won-Joong Jeong
; Jennifer Hesson
; Heriberto Cerutti
; | Date: |
22 Dec 2006 | Journal: | Science, 314 (5807), 1893 | Abstract: | Double-stranded RNA, processed to small interfering RNAs (siRNAs) by Dicer and incorporated into the RNA-induced silencing complex (RISC), triggers gene silencing by a variety of pathways in eukaryotes. RNA interference involving the degradation of homologous transcripts is the best-characterized mechanism. However, the fate of the RNA fragments resulting from siRNA-directed cleavage is poorly understood. We have identified a gene (MUT68) in the unicellular green alga Chlamydomonas reinhardtii that is required for the efficient decay of siRNA-targeted transcripts. MUT68 encodes a noncanonical polyadenylate polymerase that adds untemplated adenines to the 5’ RNA fragments after siRNA-mediated cleavage and appears to stimulate their exosome-dependent degradation. | Source: | PubMed, pmid17185594 doi: 10.1126/science.1135268 | Services: | Forum | Review | Favorites |
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