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25 April 2024 |
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Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice | | Denise L Faustman
; Simon D Tran
; Shohta Kodama
; Beatrijs M Lodde
; Ildiko Szalayova
; Sharon Key
; Zsuzsanna E Toth
; Eva Mezey
; | | Date: |
24 Nov 2006 | | Journal: | Science, 314 (5803), 1243; author reply 1243 | | Abstract: | Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery. | | Source: | PubMed, pmid17124308 doi: 10.1126/science.1129811 | | Services: | Forum | Review | Favorites | |
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