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28 March 2024
 
  » pubmed » pmid17095700

 Article overview


Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH
Anastasiya Kazantseva ; Andrey Goltsov ; Rena Zinchenko ; Anastasia P Grigorenko ; Anna V Abrukova ; Yuri K Moliaka ; Alexander G Kirillov ; Zhiru Guo ; Stephen Lyle ; Evgeny K Ginter ; Evgeny I Rogaev ;
Date 10 Nov 2006
Journal Science, 314 (5801), 982-5
AbstractThe molecular mechanisms controlling human hair growth and scalp hair loss are poorly understood. By screening about 350,000 individuals in two populations from the Volga-Ural region of Russia, we identified a gene mutation in families who show an inherited form of hair loss and a hair growth defect. Affected individuals were homozygous for a deletion in the LIPH gene on chromosome 3q27, caused by short interspersed nuclear element-retrotransposon-mediated recombination. The LIPH gene is expressed in hair follicles and encodes a phospholipase called lipase H (alternatively known as membrane-associated phosphatidic acid-selective phospholipase A1alpha), an enzyme that regulates the production of bioactive lipids. These results suggest that lipase H participates in hair growth and development.
Source PubMed, pmid17095700 doi: 10.1126/science.1133276
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