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29 March 2024
 
  » pubmed » pmid16888103

 Article overview


Human IRGM induces autophagy to eliminate intracellular mycobacteria
Sudha B Singh ; Alexander S Davis ; Gregory A Taylor ; Vojo Deretic ;
Date 8 Sep 2006
Journal Science, 313 (5792), 1438-41
AbstractImmunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
Source PubMed, pmid16888103 doi: 10.1126/science.1129577
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