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Article overview
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Human IRGM induces autophagy to eliminate intracellular mycobacteria | Sudha B Singh
; Alexander S Davis
; Gregory A Taylor
; Vojo Deretic
; | Date: |
8 Sep 2006 | Journal: | Science, 313 (5792), 1438-41 | Abstract: | Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load. | Source: | PubMed, pmid16888103 doi: 10.1126/science.1129577 | Services: | Forum | Review | Favorites |
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