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28 March 2024 |
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Article overview
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Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors | Woo-Ping Ge
; Xiu-Juan Yang
; Zhijun Zhang
; Hui-Kun Wang
; Wanhua Shen
; Qiu-Dong Deng
; Shumin Duan
; | Date: |
9 Jun 2006 | Journal: | Science, 312 (5779), 1533-7 | Abstract: | Interactions between neurons and glial cells in the brain may serve important functions in the development, maintenance, and plasticity of neural circuits. Fast neuron-glia synaptic transmission has been found between hippocampal neurons and NG2 cells, a distinct population of macroglia-like cells widely distributed in the brain. We report that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity. However, unlike the induction of LTP at many neuron-neuron synapses, both induction and expression of LTP at neuron-NG2 synapses involve Ca2+-permeable AMPA receptors on NG2 cells. | Source: | PubMed, pmid16763153 doi: 10.1126/science.1124669 | Services: | Forum | Review | Favorites |
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