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29 March 2024
 
  » pubmed » pmid16357255

 Article overview


Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics
Chung-Cheng Lee ; Guodong Sui ; Arkadij Elizarov ; Chengyi Jenny Shu ; Young-Shik Shin ; Alek N Dooley ; Jiang Huang ; Antoine Daridon ; Paul Wyatt ; David Stout ; Hartmuth C Kolb ; Owen N Witte ; Nagichettiar Satyamurthy ; James R Heath ; Michael E Phelps ; Stephen R Quake ; Hsian-Rong Tseng ;
Date 16 Dec 2005
Journal Science, 310 (5755), 1793-6
AbstractMicroreactor technology has shown potential for optimizing synthetic efficiency, particularly in preparing sensitive compounds. We achieved the synthesis of an [(18)F]fluoride-radiolabeled molecular imaging probe, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), in an integrated microfluidic device. Five sequential processes-[18F]fluoride concentration, water evaporation, radiofluorination, solvent exchange, and hydrolytic deprotection-proceeded with high radio-chemical yield and purity and with shorter synthesis time relative to conventional automated synthesis. Multiple doses of [18F]FDG for positron emission tomography imaging studies in mice were prepared. These results, which constitute a proof of principle for automated multistep syntheses at the nanogram to microgram scale, could be generalized to a range of radiolabeled substrates.
Source PubMed, pmid16357255 doi: 10.1126/science.1118919
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