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29 March 2024 |
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Article overview
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Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics | Chung-Cheng Lee
; Guodong Sui
; Arkadij Elizarov
; Chengyi Jenny Shu
; Young-Shik Shin
; Alek N Dooley
; Jiang Huang
; Antoine Daridon
; Paul Wyatt
; David Stout
; Hartmuth C Kolb
; Owen N Witte
; Nagichettiar Satyamurthy
; James R Heath
; Michael E Phelps
; Stephen R Quake
; Hsian-Rong Tseng
; | Date: |
16 Dec 2005 | Journal: | Science, 310 (5755), 1793-6 | Abstract: | Microreactor technology has shown potential for optimizing synthetic efficiency, particularly in preparing sensitive compounds. We achieved the synthesis of an [(18)F]fluoride-radiolabeled molecular imaging probe, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), in an integrated microfluidic device. Five sequential processes-[18F]fluoride concentration, water evaporation, radiofluorination, solvent exchange, and hydrolytic deprotection-proceeded with high radio-chemical yield and purity and with shorter synthesis time relative to conventional automated synthesis. Multiple doses of [18F]FDG for positron emission tomography imaging studies in mice were prepared. These results, which constitute a proof of principle for automated multistep syntheses at the nanogram to microgram scale, could be generalized to a range of radiolabeled substrates. | Source: | PubMed, pmid16357255 doi: 10.1126/science.1118919 | Services: | Forum | Review | Favorites |
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