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The genome of the kinetoplastid parasite, Leishmania major | | Alasdair C Ivens
; Christopher S Peacock
; Elizabeth A Worthey
; Lee Murphy
; Gautam Aggarwal
; Matthew Berriman
; Ellen Sisk
; Marie-Adele Rajandream
; Ellen Adlem
; Rita Aert
; Atashi Anupama
; Zina Apostolou
; Philip Attipoe
; Nathalie Bason
; Christopher Bauser
; Alfred Beck
; Stephen M Beverley
; Gabriella Bianchettin
; Katja Borzym
; Gordana Bothe
; Carlo V Bruschi
; Matt Collins
; Eithon Cadag
; Laura Ciarloni
; Christine Clayton
; Richard M R Coulson
; Ann Cronin
; Angela K Cruz
; Robert M Davies
; Javier De Gaudenzi
; Deborah E Dobson
; Andreas Duesterhoeft
; Gholam Fazelina
; Nigel Fosker
; Alberto Carlos Frasch
; Audrey Fraser
; Monika Fuchs
; Claudia Gabel
; Arlette Goble
; André Goffeau
; David Harris
; Christiane Hertz-Fowler
; Helmut Hilbert
; David Horn
; Yiting Huang
; Sven Klages
; Andrew Knights
; Michael Kube
; Natasha Larke
; Lyudmila Litvin
; Angela Lord
; Tin Louie
; Marco Marra
; David Masuy
; Keith Matthews
; Shulamit Michaeli
; Jeremy C Mottram
; Silke Müller-Auer
; Heather Munden
; Siri Nelson
; Halina Norbertczak
; Karen Oliver
; Susan O’neil
; Martin Pentony
; Thomas M Pohl
; Claire Price
; Bénédicte Purnelle
; Michael A Quail
; Ester Rabbinowitsch
; Richard Reinhardt
; Michael Rieger
; Joel Rinta
; Johan Robben
; Laura Robertson
; Jeronimo C Ruiz
; Simon Rutter
; David Saunders
; Melanie Schäfer
; Jacquie Schein
; David C Schwartz
; Kathy Seeger
; Amber Seyler
; Sarah Sharp
; Heesun Shin
; Dhileep Sivam
; Rob Squares
; Steve Squares
; Valentina Tosato
; Christy Vogt
; Guido Volckaert
; Rolf Wambutt
; Tim Warren
; Holger Wedler
; John Woodward
; Shiguo Zhou
; Wolfgang Zimmermann
; Deborah F Smith
; Jenefer M Blackwell
; Kenneth D Stuart
; Bart Barrell
; Peter J Myler
; | | Date: |
15 Jul 2005 | | Journal: | Science, 309 (5733), 436-42 | | Abstract: | Leishmania species cause a spectrum of human diseases in tropical and subtropical regions of the world. We have sequenced the 36 chromosomes of the 32.8-megabase haploid genome of Leishmania major (Friedlin strain) and predict 911 RNA genes, 39 pseudogenes, and 8272 protein-coding genes, of which 36% can be ascribed a putative function. These include genes involved in host-pathogen interactions, such as proteolytic enzymes, and extensive machinery for synthesis of complex surface glycoconjugates. The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryp) genomes suggest that the mechanisms regulating RNA polymerase II-directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling. Abundant RNA-binding proteins are encoded in the Tritryp genomes, consistent with active posttranscriptional regulation of gene expression. | | Source: | PubMed, pmid16020728 doi: 10.1126/science.1112680 | | Services: | Forum | Review | Favorites | |
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