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29 March 2024
 
  » pubmed » pmid15326355

 Article overview


Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling
Michele A West ; Robert P A Wallin ; Stephen P Matthews ; Henrik G Svensson ; Rossana Zaru ; Hans-Gustaf Ljunggren ; Alan R Prescott ; Colin Watts ;
Date 20 Aug 2004
Journal Science, 305 (5687), 1153-7
AbstractMicrobial products are sensed through Toll-like receptors (TLRs) and trigger a program of dendritic cell (DC) maturation that enables DCs to activate T cells. Although an accepted hallmark of this response is eventual down-regulation of DC endocytic capacity, we show that TLR ligands first acutely stimulate antigen macropinocytosis, leading to enhanced presentation on class I and class II major histocompatibility complex molecules. Simultaneously, actin-rich podosomes disappear, which suggests a coordinated redeployment of actin to fuel endocytosis. These reciprocal changes are transient and require p38 and extracellular signal-regulated kinase activation. Thus, the DC actin cytoskeleton can be rapidly mobilized in response to innate immune stimuli to enhance antigen capture and presentation.
Source PubMed, pmid15326355 doi: 10.1126/science.1099153
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