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Crystal structure of a shark single-domain antibody V region in complex with lysozyme | | Robyn L Stanfield
; Helen Dooley
; Martin F Flajnik
; Ian A Wilson
; | | Date: |
17 Sep 2004 | | Journal: | Science, 305 (5691), 1770-3 | | Abstract: | Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies. | | Source: | PubMed, pmid15319492 doi: 10.1126/science.1101148 | | Services: | Forum | Review | Favorites | |
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