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23 April 2024

» pubmed » pmid15166379

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CD8+ T cell cross-priming via transfer of proteasome substrates
Christopher C Norbury ; Sameh Basta ; Keri B Donohue ; David C Tscharke ; Michael F Princiotta ; Peter Berglund ; James Gibbs ; Jack R Bennink ; Jonathan W Yewdell ;
Date:	28 May 2004
Journal:	Science, 304 (5675), 1318-21
Abstract:	"Cross-priming" describes the activation of naïve CD8+ T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from "donor" cells. Antigen transfer is believed to be mediated by donor cell-derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8+ T cell responses.
Source:	PubMed, pmid15166379 doi: 10.1126/science.1096378
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