Research articles

search articles

My Pages

Stat

Members: 3645
Articles: 2'503'724
Articles rated: 2609

23 April 2024

» pubmed » pmid15001714

Article overview

An antigenic peptide produced by peptide splicing in the proteasome
Nathalie Vigneron ; Vincent Stroobant ; Jacques Chapiro ; Annie Ooms ; Gérard Degiovanni ; Sandra Morel ; Pierre van der Bruggen ; Thierry Boon ; Benoît J Van den Eynde ;
Date:	23 Apr 2004
Journal:	Science, 304 (5670), 587-90
Abstract:	CD8 T lymphocytes recognize peptides of 8 to 10 amino acids presented by class I molecules of the major histocompatibility complex. Here, CD8 T lymphocytes were found to recognize a nonameric peptide on melanoma cells that comprises two noncontiguous segments of melanocytic glycoprotein gp100(PMEL17). The production of this peptide involves the excision of four amino acids and splicing of the fragments. This process was reproduced in vitro by incubating a precursor peptide of 13 amino acids with highly purified proteasomes. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. Our results reveal an unanticipated aspect of the proteasome function of producing antigenic peptides.
Source:	PubMed, pmid15001714 doi: 10.1126/science.1095522
Services:	Forum \| Review \| Favorites

No review found.

Did you like this article?

This article or document is ...
important:
of broad interest:
readable:
new:
correct:
Global appreciation:

Note: answers to reviews or questions about the article must be posted in the forum section.
Authors are not allowed to review their own article. They can use the forum section.

browser Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

ScienXe.org
» my Online CV
» Free

News, job offers and information for researchers and scientists:

home

contact

sitemap