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Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase | | Astrid A Ruefli-Brasse
; Dorothy M French
; Vishva M Dixit
; | | Date: |
28 Nov 2003 | | Journal: | Science, 302 (5650), 1581-4 | | Abstract: | Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor kappaB (NF-kappaB) activation. We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor-induced NF-kappaB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-kappaB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the IkappaB kinase complex. | | Source: | PubMed, pmid14576442 doi: 10.1126/science.1090769 | | Services: | Forum | Review | Favorites | |
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