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29 March 2024
 
  » pubmed » pmid12730500

 Article overview


Characterization of a novel coronavirus associated with severe acute respiratory syndrome
Paul A Rota ; M Steven Oberste ; Stephan S Monroe ; W Allan Nix ; Ray Campagnoli ; Joseph P Icenogle ; Silvia Peñaranda ; Bettina Bankamp ; Kaija Maher ; Min-Hsin Chen ; Suxiong Tong ; Azaibi Tamin ; Luis Lowe ; Michael Frace ; Joseph L DeRisi ; Qi Chen ; David Wang ; Dean D Erdman ; Teresa C T Peret ; Cara Burns ; Thomas G Ksiazek ; Pierre E Rollin ; Anthony Sanchez ; Stephanie Liffick ; Brian Holloway ; Josef Limor ; Karen McCaustl ; Melissa Olsen-Rasmussen ; Ron Fouchier ; Stephan Günther ; Albert D M E Osterhaus ; Christian Drosten ; Mark A Pallansch ; Larry J Anderson ; William J Bellini ;
Date 30 May 2003
Journal Science, 300 (5624), 1394-9
AbstractIn March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
Source PubMed, pmid12730500 doi: 10.1126/science.1085952
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