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26 April 2024 |
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Induction of tumors in mice by genomic hypomethylation | | François Gaudet
; J Graeme Hodgson
; Amir Eden
; Laurie Jackson-Grusby
; Jessica Dausman
; Joe W Gray
; Heinrich Leonhardt
; Rudolf Jaenisch
; | | Date: |
18 Apr 2003 | | Journal: | Science, 300 (5618), 489-92 | | Abstract: | Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1 (Dnmt1) allele, which reduces Dnmt1 expression to 10% of wild-type levels and results in substantial genome-wide hypomethylation in all tissues. The mutant mice were runted at birth, and at 4 to 8 months of age they developed aggressive T cell lymphomas that displayed a high frequency of chromosome 15 trisomy. These results indicate that DNA hypomethylation plays a causal role in tumor formation, possibly by promoting chromosomal instability. | | Source: | PubMed, pmid12702876 doi: 10.1126/science.1083558 | | Services: | Forum | Review | Favorites | |
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