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19 April 2024

» pubmed » pmid12364791

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The genome sequence of the malaria mosquito Anopheles gambiae
Robert A Holt ; G Mani Subramanian ; Aaron Halpern ; Granger G Sutton ; Rosane Charlab ; Deborah R Nusskern ; Patrick Wincker ; Andrew G Clark ; José M C Ribeiro ; Ron Wides ; Steven L Salzberg ; Brendan Loftus ; Mark Yandell ; William H Majoros ; Douglas B Rusch ; Zhongwu Lai ; Cheryl L Kraft ; Josep F Abril ; Veronique Anthouard ; Peter Arensburger ; Peter W Atkinson ; Holly Baden ; Veronique de Berardinis ; Danita Baldwin ; Vladimir Benes ; Jim Biedler ; Claudia Blass ; Randall Bolanos ; Didier Boscus ; Mary Barnstead ; Shuang Cai ; Angela Center ; Kabir Chaturverdi ; George K Christophides ; Mathew A Chrystal ; Michele Clamp ; Anibal Cravchik ; Val Curwen ; Ali Dana ; Art Delcher ; Ian Dew ; Cheryl A Evans ; Michael Flanigan ; Anne Grundschober-Freimoser ; Lisa Friedli ; Zhiping Gu ; Ping Guan ; Roderic Guigo ; Maureen E Hillenmeyer ; Susanne L Hladun ; James R Hogan ; Young S Hong ; Jeffrey Hoover ; Olivier Jaillon ; Zhaoxi Ke ; Chinnappa Kodira ; Elena Kokoza ; Anastasios Koutsos ; Ivica Letunic ; Alex Levitsky ; Yong Liang ; Jhy-Jhu Lin ; Neil F Lobo ; John R Lopez ; Joel A Malek ; Tina C McIntosh ; Stephan Meister ; Jason Miller ; Clark Mobarry ; Emmanuel Mongin ; Sean D Murphy ; David A O’Brochta ; Cynthia Pfannkoch ; Rong Qi ; Megan A Regier ; Karin Remington ; Hongguang Shao ; Maria V Sharakhova ; Cynthia D Sitter ; Jyoti Shetty ; Thomas J Smith ; Renee Strong ; Jingtao Sun ; Dana Thomasova ; Lucas Q Ton ; Pantelis Topalis ; Zhijian Tu ; Maria F Unger ; Brian Walenz ; Aihui Wang ; Jian Wang ; Mei Wang ; Xuelan Wang ; Kerry J Woodford ; Jennifer R Wortman ; Martin Wu ; Alison Yao ; Evgeny M Zdobnov ; Hongyu Zhang ; Qi Zhao ; Shaying Zhao ; Shiaoping C Zhu ; Igor Zhimulev ; Mario Coluzzi ; Alessandra della Torre ; Charles W Roth ; Christos Louis ; Francis Kalush ; Richard J Mural ; Eugene W Myers ; Mark D Adams ; Hamilton O Smith ; Samuel Broder ; Malcolm J Gardner ; Claire M Fraser ; Ewan Birney ; Peer Bork ; Paul T Brey ; J Craig Venter ; Jean Weissenbach ; Fotis C Kafatos ; Frank H Collins ; Stephen L Hoffman ;
Date:	4 Oct 2002
Journal:	Science, 298 (5591), 129-49
Abstract:	Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent existence of two haplotypes of approximately equal frequency ("dual haplotypes") in a substantial fraction of the genome likely reflects the outbred nature of the PEST strain. The sequence produced a conservative inference of more than 400,000 single-nucleotide polymorphisms that showed a markedly bimodal density distribution. Analysis of the genome sequence revealed strong evidence for about 14,000 protein-encoding transcripts. Prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted. An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect.
Source:	PubMed, pmid12364791 doi: 10.1126/science.1076181
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