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29 March 2024
 
  » pubmed » pmid11786643

 Article overview


Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
Susetta Finotto ; Markus F Neurath ; Jonathan N Glickman ; Shixin Qin ; Hans A Lehr ; Francis H Y Green ; Kate Ackerman ; Kathleen Haley ; Peter R Galle ; Susanne J Szabo ; Jeffrey M Drazen ; George T De Sanctis ; Laurie H Glimcher ;
Date 11 Jan 2002
Journal Science, 295 (5553), 336-8
AbstractHuman asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.
Source PubMed, pmid11786643 doi: 10.1126/science.1065544
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