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18 April 2024 |
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Article overview
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Glycolipid antigen processing for presentation by CD1d molecules | | T I Prigozy
; O Naidenko
; P Qasba
; D Elewaut
; L Brossay
; A Khurana
; T Natori
; Y Koezuka
; A Kulkarni
; M Kronenberg
; | | Date: |
26 Jan 2001 | | Journal: | Science, 291 (5504), 664-7 | | Abstract: | The requirement for processing glycolipid antigens in T cell recognition was examined with mouse CD1d-mediated responses to glycosphingolipids (GSLs). Although some disaccharide GSL antigens can be recognized without processing, the responses to three other antigens, including the disaccharide GSL Gal(alpha1-->2)GalCer (Gal, galactose; GalCer, galactosylceramide), required removal of the terminal sugars to permit interaction with the T cell receptor. A lysosomal enzyme, alpha-galactosidase A, was responsible for the processing of Gal(alpha1-->2)GalCer to generate the antigenic monosaccharide epitope. These data demonstrate a carbohydrate antigen processing system analogous to that used for peptides and an ability of T cells to recognize processed fragments of complex glycolipids. | | Source: | PubMed, pmid11158680 doi: 10.1126/science.291.5504.664 | | Services: | Forum | Review | Favorites | |
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