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29 March 2024
 
  » pubmed » pmid9924026

 Article overview


T lymphocyte costimulation mediated by reorganization of membrane microdomains
A Viola ; S Schroeder ; Y Sakakibara ; A Lanzavecchia ;
Date 29 Jan 1999
Journal Science, 283 (5402), 680-2
AbstractAlthough dispensable, costimulation through CD28 facilitates activation of naïve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.
Source PubMed, pmid9924026
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