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29 March 2024 |
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T lymphocyte costimulation mediated by reorganization of membrane microdomains | A Viola
; S Schroeder
; Y Sakakibara
; A Lanzavecchia
; | Date: |
29 Jan 1999 | Journal: | Science, 283 (5402), 680-2 | Abstract: | Although dispensable, costimulation through CD28 facilitates activation of naïve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains. | Source: | PubMed, pmid9924026 | Services: | Forum | Review | Favorites |
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