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Fusion-competent vaccines: broad neutralization of primary isolates of HIV | | R A LaCasse
; K E Follis
; M Trahey
; J D Scarborough
; D R Littman
; J H Nunberg
; | | Date: |
15 Jan 1999 | | Journal: | Science, 283 (5400), 357-62 | | Abstract: | Current recombinant human immunodeficiency virus (HIV) gp120 protein vaccine candidates are unable to elicit antibodies capable of neutralizing infectivity of primary isolates from patients. Here, "fusion-competent" HIV vaccine immunogens were generated that capture the transient envelope-CD4-coreceptor structures that arise during HIV binding and fusion. In a transgenic mouse immunization model, these formaldehyde-fixed whole-cell vaccines elicited antibodies capable of neutralizing infectivity of 23 of 24 primary HIV isolates from diverse geographic locations and genetic clades A to E. Development of these fusion-dependent immunogens may lead to a broadly effective HIV vaccine. | | Source: | PubMed, pmid9888845 | | Services: | Forum | Review | Favorites | |
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