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IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling | | M Muzio
; J Ni
; P Feng
; V M Dixit
; | | Date: |
28 Nov 1997 | | Journal: | Science, 278 (5343), 1612-5 | | Abstract: | The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation. | | Source: | PubMed, pmid9374458 | | Services: | Forum | Review | Favorites | |
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