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19 April 2024 |
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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | | D Stokoe
; L R Stephens
; T Copel
; P R Gaffney
; C B Reese
; G F Painter
; A B Holmes
; F McCormick
; P T Hawkins
; | | Date: |
25 Jul 1997 | | Journal: | Science, 277 (5325), 567-70 | | Abstract: | Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase. Chromatographic separation of brain cytosol revealed a kinase activity that phosphorylated and activated PKB only in the presence of phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P3]. Phosphorylation occurred exclusively on threonine-308, a residue implicated in activation of PKB in vivo. PtdIns(3,4,5)P3 was determined to have a dual role: Its binding to the pleckstrin homology domain of PKB was required to allow phosphorylation by the upstream kinase and it directly activated the upstream kinase. | | Source: | PubMed, pmid9228007 | | Services: | Forum | Review | Favorites | |
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