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The receptor for the cytotoxic ligand TRAIL | | G Pan
; K O’Rourke
; A M Chinnaiyan
; R Gentz
; R Ebner
; J Ni
; V M Dixit
; | | Date: |
4 Apr 1997 | | Journal: | Science, 276 (5309), 111-3 | | Abstract: | TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis. | | Source: | PubMed, pmid9082980 | | Services: | Forum | Review | Favorites | |
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